How is wet AMD treated?
A protein called vascular endothelial growth factor (VEGF) is produced in our body and regulates the growth of blood vessels. In wet AMD, an excess of VEGF causes the formation of abnormal vessels. Several anti-VEGF medications are available to inactivate the excess VEGF. These drugs need to be injected into the eye. This is called an intravitreal injection. Anti-VEGF injections have led to remarkable gains in vision. These treatments are initially done monthly. As the eye improves, treatments become less frequent and in time may be paused. While most patients initially have an aversion to the idea of an injection into the eye, numbing of the eye is carefully done, these injections are comfortable, and patients do very well.
Since intravitreal injections typically provide the best outcomes, it is less common to use other treatments, such as a cold laser (Visudyne Photodynamic Therapy) or thermal laser treatment to seal the leaky blood vessels. Photodynamic treatment uses a medication, Visudyne, that is absorbed by the leaky blood vessels. A laser light activates the drug, causing the blood vessels to close and stop leaking. Thermal laser treatment seals leaky blood vessels but damages the tissue, so it is usually used when the leaky vessels are farther away from the center of vision.